K Vitamin Dependent Factors

Deficiency in the vitamin k dependent factor ii prothrombin can be.

K vitamin dependent factors. The child grew up got 10 upon 10 marks. Acquired forms of the disorder can be caused by intestinal malabsorption of vitamin k. Key vitamin k dependent factors. Occurrence of vitamin k deficiency bleeding in the first week of the infant s life is estimated at 0 25 1 7 with a prevalence of 2 10 cases per 100 000 births.

Prothrombin alone needs vitamin k to modify 10 different regions within the protein for functionality. Four other proteins. Factor ii is alternatively named prothrombin. Also anticoagulation proteins c s and z as well as osteocalcin and the matrix gla protein depend on vitamin k.

This appears to be a consequence of poor transfer of the vitamin across the placenta and thus low fetal plasma vitamin k. Familial multiple coagulation factor deficiency is rare. Vitamin k is important in the steps involving protein factor ii vii ix and x 1. Vitamin k is an essential factor to a hepatic gamma glutamyl carboxylase that adds a carboxyl group to glutamic acid residues on factors ii vii ix and x as well as protein s protein c and protein z.

In year 2k 2000 factor 2 is k dependant a pregnant lady after carrying her child for 9 months caring all 7 days a week gave birth to a child. The blood clotting factors of newborn babies are roughly 30 60 that of adult values. Deficiency in any of these factors can disrupt the clotting process and result in a range of bleeding problems. In adding the gamma carboxyl group to glutamate residues on the immature clotting factors vitamin k is itself oxidized.

The main vitamin k dependent coagulation proteins are factor ii also known as prothrombin and factors vii ix and x. In order to continue the chain reaction of the coagulation cascade these four factors need to be activated in a chemical reaction that involves vitamin k. Any of a group of coagulation factor proenzymes factors ii vii ix and x produced in the liver that contain multiple residues of gamma carboxyglutamic acid an amino acid produced by the post translational action of a vitamin k dependent gamma carboxylase on certain glutamyl residues. Inherited combined deficiency of the vitamin k dependent clotting factors vkcfd is a very rare inherited bleeding disorder that is caused by a problem with clotting factors ii vii ix and x.

It is commonly used for prevention and treatment of vte prevention of stroke in atrial fibrillation anticoagulation for mechanical prosthetic heart valves and myocardial infarction prevention in coronary artery disease. Warfarin 4 hydroxycoumarin inhibits the synthesis of vitamin k dependent coagulation factors including factors ii vii ix and x as well as proteins c and s. Deficiency of all vitamin k dependent clotting factors leads to a bleeding tendency that is usually reversed by oral administration of vitamin k. 127 129 these rare autosomal recessive disorders have an estimated incidence of 1.

To remember the vitamin k dependent factors try to memorize this picture. Vitamin k dependent clotting factor.